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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

O. Voznesensky

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2 papers indexed here

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Oct 2026

Acute MCL1 Loss via Homoharringtonine-Mediated Translational Inhibition Enables Potent Apoptotic Synergy with BCLXL Blockade.

Antiapoptotic buffering in solid tumors is generally mediated by both BCLXL and MCL1, so that BH3 mimetic drugs targeting only one have limited efficacy. To identify agents that may sensitize tumors to BH3 mimetics targeting BCLXL, we screened prostate cancer cells against a panel of mitochondria-targeted drugs in comb...

Akira Ohtsu, Tatsuhiro Sawada, L. Poluben et al. · 0 citations
Open access Aug 2026

Tumor-adjacent B cell infiltration stratifies recurrence risk in localized prostate cancer

Background: Biochemical recurrence (BCR) occurs in 20-40% of men after radical prostatectomy. Existing postoperative recurrence risk tools based on PSA and pathology are clinically useful but show only moderate and variable discrimination, highlighting the need for biomarkers that improve risk stratification and conseq...

B. Wang, S. Mukherjee, A. Baj et al. · 0 citations

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