Investigation of the Bcl-2 Inhibition Potential of Drugs Withdrawn from the Clinic Using in silico Methods
Apoptosis is essential for tissue homeostasis, and its dysregulation is a hallmark of cancer. The B-cell lymphoma-2 (Bcl-2) protein family, particularly known for its anti-apoptotic role, contributes to tumor survival and chemoresistance. Venetoclax, a selective Bcl-2 inhibitor, has shown notable clinical success; howe...