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Oksana Pichurin

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Open access Aug 2026

Inhibition of EED enhances osteogenic differentiation and bone formation: a potential therapeutic strategy for osteogenesis imperfecta

It is demonstrated that inhibition of the PRC2 through targeting its essential component embryonic ectoderm development (EED) enhances osteogenic differentiation, improves bone architecture in male Col1a2+/G610C OI mouse models, modulates the integrated stress response (ISR), and improves ER morphology in OI cells.

Margarita E. Carrasco Jeldres, Oksana Pichurin, S. Weaver et al. · 0 citations

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