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Author

Oksana Polesskaya

2 papers indexed here

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Open access Aug 2026

Trex-QTL: A mixture-model for identification of genetic effects with global effects on molecular phenotypes

While thousands of cis expression quantitative trait loci (cis-eQTLs) have been reliably identified, detecting trans-eQTL effects has proven to be challenging due to insufficient statistical power, lack of comparable tissues and cohorts, and low reproducibility across studies. Here, we present Trex-QTL, a novel trans-e...

Cynthia Wu, Andrey V. Bzikadze, Tian-Yao Xu et al. · 0 citations
Open access Sep 2026

Point mutations and complex variants impact gene expression and addiction-related behaviors in Heterogeneous Stock rats

While various variants, including single nucleotide polymorphisms (SNPs), small insertions/deletions, short tandem repeats and structural variants, drive individual genetic differences, their influence on gene expression and complex traits remains unclear. We used short- and long-read sequencing to generate a comprehen...

Denghui Chen, Katarina A. Cohen, Khai-Minh H. Nguyen et al. · 0 citations

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