Author

Olaf Witt

3 papers indexed here

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Open access Sep 2026

Interdisciplinary management and genetic evaluation of pediatric cancer predisposition syndromes: a retrospective cohort study.

The interdisciplinary CPS consultation model contributes to identifying hereditary cancer predisposition in pediatric patients and families and provides a scalable foundation for systematic CPS assessment and development of standardized, evidence-based surveillance protocols in pediatric oncology.

N. Dikow, Anna-Katharina Nitschke, S. Hirsch et al. · European Journal of Human Ge... · 0 citations

Open access Sep 2026

Functional proteomic and phosphoproteomic profiling of routine FFPE CNS tumor tissue complements genomic and epigenomic characterization

Genomic and DNA methylation-based analyses have transformed the classification of central nervous system (CNS) tumors by enabling robust molecular diagnosis and subclassification. However, these approaches primarily define tumor identity and do not directly capture the functional state of intracellular signaling networ...

Dennis Friedel, Rhaissa Ribeiro da Silva, Ivan Abdulrazak Ahmed et al. · Acta Neuropathologica · 0 citations

Open access Jul 2026

Circulating tumor DNA precision oncology enables effective and sensitive molecular diagnostics and actionable target detection in pediatric solid tumors - the INFORM experience

By optimizing preanalytical and bioinformatic tools for pediatric settings, this study improved plasma-based cancer detection, molecular tumor characterization, and identification of targetable alterations, laying the groundwork for integration into personalized medicine programs and clinical trials.

K. Maass, P. Puranachot, S. Volz et al. · Genome Medicine · 0 citations