Oleg V. Kim

Early emergence of contractility and mechanotransduction during human megakaryopoiesis

Abstract The ability to contract blood clots is a hallmark of functional platelets. Proteins that support agonist-induced platelet contraction are expressed in megakaryocytes (MKs) and transferred to platelets during thrombopoiesis. Here, we investigated when during MK development the functional machinery for contracti...