Olga Nikolova

Unifying multimodal single-cell data with a mixture-of-experts β-variational autoencoder framework

Multimodal single-cell assays profile complementary layers of cell state, but integration is complicated by modality mismatch, sparsity, and uneven cohort coverage. Here, we present Unified Variational Inference (UniVI), a scalable mixture-of-experts β-variational autoencoder that learns a shared latent space while pre...