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Oliver Knowles

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Open access Sep 2026

Molecular architecture and spatial organization of proteasomes in the human sperm nucleus

In situ cryo-electron tomography in human sperm cells is used to elucidate the molecular architecture of nuclear proteasomes, which cluster in DNA-free, nuclear cavities within the sperm nucleus, and resolves a native peptide in the catalytic β2 subunit, providing insight into the proteolysis mechanism and PA200-mediat...

P. Kolata, Ália dos Santos, Oliver Knowles et al. · 0 citations

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