Hormone Replacement Therapy Is Associated with Increased Risk of Anterior Cruciate Ligament Tear in Midlife Women in the United States
Background: Across the female lifespan, the incidence of anterior cruciate ligament (ACL) tears has demonstrated a bimodal age distribution, and this may be related to fluctuating lifetime estrogen. However, this relationship—and the role of hormone replacement therapy (HRT) and its potentially modifying effect on ACL...