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Author

Olivia N. Beshay

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Open access Sep 2026

Aucubin Ameliorates Alloxan-Induced Diabetic Liver Injury in Association with Modulation of the Nrf2/HO-1 Antioxidant Axis and NF-κB-Associated Inflammatory and Apoptotic Signaling

Diabetes mellitus is associated with progressive hepatic injury driven by oxidative stress, inflammation, and apoptosis. Aucubin, a natural iridoid glycoside, possesses potent antioxidant and anti-inflammatory activities; however, its hepatoprotective mechanisms in diabetic liver injury remain unclear. This study inves...

Amany M. Hamed, N. Mahrous, Safaa S. Soliman et al. · 0 citations
Open access Jul 2026

Rupatadine Ameliorates Cisplatin‐Induced Hepatotoxicity in Rats: Targeting HMGB1/TLR4/NF‐κB and NLRP3/Caspase‐1 Signaling Pathways

RUPA counteracts hepatotoxicity evoked by CISP in rats via its anti‐oxidative as well as anti‐inflammatory properties via repression of hepatic HMGB1/TLR4/NF‐κB and thus restricts the activation of NLRP3/caspase‐1 signaling cascade.

Shaimaa Mohamed Abdelrahman, A. Bekhit, Olivia N. Beshay · 0 citations

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