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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Olivier Cuvier

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Open access Oct 2026

MacroH2A1 and H3K27me3 target cGAS to facultative heterochromatin to restrain innate immune activation

The DNA sensor cGAS is largely sequestered on chromatin in an inactive form, but how this state is regulated remains unclear. We show that cGAS preferentially binds nucleosomes containing the histone variant macroH2A1 (mH2A1) marked by H3K27me3 and H3K9me3. Cryo-EM reveals that cGAS selectively engages the mH2A1/H2B ac...

Suzie Thenin-Houssier, Cyprien Jahan, Wen-Jie Xu et al. · 0 citations
Open access Aug 2025

Nuclear exosome targeting complexes modulate cohesin binding and enhancer-promoter interactions in 3D

Three-dimensional long-range contacts between enhancers and promoters are thought to be largely determined by loop extrusion driven by the cohesin complex and insulator factors. However, recent evidence also suggests a role for noncoding RNAs (ncRNAs), such as enhancer-associated RNAs (eRNAs) and promoter upstream tran...

Charbel Akkawi, Alexandre Heurteau, Xavier Contreras et al. · 1 citation · ⚡1

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