Extrachromosomal DNA (ecDNA) has been identified as a critical component of tumour evolution, offering a dynamic genetic and regulatory landscape through which cancer cells can alter oncogene dosage, transcriptional states, and cellular phenotypes. Lacking centromeric and telomeric sequences, ecDNA is inherited in a no...
Verity Ghansah, Yemisi Omotoyosi Adetayo, Oluwabukunmi M. Oluwaniran et al.· Oncology, Nuclear Medicine a...· 0 citations
A new conceptual model is introduced, called the Integrated Functional Precision Oncology (IFPO) Framework, that brings together functional genomic perturbation, single-cell multi-omics, computational systems biology, and clinical translation and offers directions for further progress of precision cancer treatment base...
O. Oluwadare, M. Frankpeace, Oluwabukunmi M. Oluwaniran et al.· Oncology, Nuclear Medicine a...· 1 citation
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