Óscar López

Oleanolic acid-selenocyanate hybrids trigger replication-associated DNA damage responses and suppress tumour growth in vitro and in vivo.

Oleanolic acid (OA) is a privileged pentacyclic triterpenoid scaffold displaying moderate antiproliferative properties, whereas selenocyanates are recognized organoselenium pharmacophores with promising anticancer potential. To explore possible synergistic effects, we designed and synthesized an unprecedented library o...