Author

Owen M. Wilkins

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Jul 2026

PI3K Delta Inhibition Alters CD8 T Cell Différentiation and Reprograms the Tumor Microenvironment Following Adoptive Immunotherapy 2247548

PI3Kδ inhibition programs T cells with stemness and metabolic fitness that favor Tpex differentiation, resist terminal exhaustion, and remodel the TME toward an inflammatory state, supporting a practical strategy to improve ACT efficacy in solid tumors.

Alexandrea Turnquist, Azka Javaid, F. Kolling et al. · Journal of Immunology · 0 citations