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P. A

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Review Open access Sep 2026

The HIF-1α–Mitochondria Axis in Alzheimer's Disease: Therapeutic Potential of Roxadustat in Restoring Neuronal Bioenergetics and Cognitive Function

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) plaques, tau pathology, mitochondrial dysfunction, oxidative stress, neuroinflammation, and cerebral hypoperfusion. Emerging evidence suggests that dysregulation of the hypoxia-inducible factor-1 alpha (HIF-1α)-mitochon...

R. Elavarasi, P. A, V. R et al. · 0 citations

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