Author

P. A. Barbugli

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Open access Aug 2026

Zerumbone Combined with Hydrolytic Enzymes: A Promising Strategy to Control Mixed Biofilms of Streptococcus mutans and Fluconazole-Resistant Candida albicans

This in vitro study evaluated the efficacy of Zerumbone (ZER), a sesquiterpene phytochemical extracted from the rhizomes of Zingiber zerumbet (L.) Smith with reported antimicrobial properties, alone or combined with Dextranase (DEX) and DNase I (DNase), against polymicrobial biofilms of fluconazole-susceptible and fluc...

A. D. de Oliveira, B. H. D. Panariello, P. A. Barbugli et al. · ACS Omega · 0 citations

Open access Sep 2026

Zerumbone combined with antimicrobial photodynamic inactivation reduces growth of Candida albicans biofilms and modulates virulence gene expression.

It is demonstrated that the association of ZER and aPDI exerts a potent multimodal effect by disrupting the biofilm's physical architecture, attenuating fungal pathogenicity and antioxidant defenses, and suppressing ergosterol biosynthesis, thereby offering a significant antifungal effect.

Juliana Cerini Grassi de Moraes, C. Jordão, P. A. Barbugli et al. · Photochemical and Photobiolo... · 0 citations

Open access Aug 2026

Smart Coatings Integrating Antimicrobial and Tissue-Remodeling Functions for Implant Interfaces.

The multifunctional coating provides sustained antimicrobial activity alongside immunomodulatory and pro-regenerative effects, supporting its potential to treat implant-related infections while enhancing peri-implant soft tissue remodeling.

Mariana Martins Guerreiro, Amanda Paino Santana, D. M. Cunha et al. · Journal of Periodontal Resea... · 0 citations