Author

P. Adams

2 papers indexed here

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Open access Jul 2026

Mitochondrial metabolism and epigenetic crosstalk drive SASP

It is shown that mitochondrial metabolism provides a second layer of control that enables execution of the inflammatory programme, and a mechanism that selectively controls the inflammatory output of senescent cells is revealed.

Hélène Martini, Jodie Birch, Francisco D M Marques et al. · Nature · 3 citations

Open access Aug 2026

High-Specificity Detection of Chromosomal Mosaicism Reveals Cell-Type-Specific Genomic Alteration Patterns in Aging Tissues

Mosaic chromosomal alterations (mCAs) increase with age and are associated with multiple diseases, yet the cell types and states that harbor these alterations remain largely unknown. Because mCAs arise in individual cells prior to clonal expansion, they are typically rare and obscured in bulk data. We develop CHASM, a...

Xinyi E. Chen, Hanzhi Wang, Yilin Yang et al. · bioRxiv · 0 citations