Serum-Cecal Metabolome Integration Predicts Gut Microbial Communities and Reveals Pathway-Level Host-Microbe Crosstalk Under Disease-Induced Dysbiosis.
An integrative multi-omics framework combining serum and cecal metabolomics with 16S rRNA-based microbiome profiling is developed, establishing a multi-omics strategy for predictive inference of gut microbial composition from host metabolomes and providing a framework for identifying pathway-level mechanisms underlying...