A meta-GWAS with seven studies of European ancestry identified for the first time a robust chromosomal region associated with emotional eating in seven studies, supporting the hypothesis that shared genetic factors may influence both eating behavior traits and obesity risk.
M. Muntaner, K. Horn, B. de Lauzon-Guillain et al.· Molecular Psychiatry· 0 citations
A validated WMH global-PRS is generated showing robust association with cSVD clinical complications and introduce a multi-cohort WMH ps-PRS framework that reveals candidate biological pathways with candidate biological associations across the lifespan and clinical outcomes.
T. D'Aoust, A. Tsuchida, C. Dufouil et al.· medRxiv· 0 citations
It is demonstrated that downregulation of PLCG2, primarily in neurons, impairs synaptic function and elevates amyloid-β levels and Tau protein phosphorylation in neurons.
Audrey Coulon, F. Rabiller, M. Takalo et al.· Nature Genetics· 0 citations
It is concluded that rare coding CNVs in a proportion of AD-associated genes and 22q11.21 duplication as a strong AD-risk-decreasing factor increase AD risk and Conversely, 22q11.21 duplication as a strong AD-risk-decreasing factor is identified.
O. Quenez, Catherine Schramm, K. Cassinari et al.· American Journal of Human Ge...· 1 citation
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