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Open access Jul 2026

Targeting genome organizer Satb1 in regulatory T cells safely and potently enhances cancer immunity 2309560

Deletion of Satb1 specifically in Tregs impaired the function of Satb1+ pro-tumorigenic Tregs, leading to enhanced CD8+ T cell antitumor immune responses, and complete tumor eradication without any systemic autoimmune conditions.

Ephraim A. Ansa-Addo, Parviz Azimnasab-sorkhabi, Musab Bouhajra et al. · 0 citations