P. Buenzli

Rethinking osteocyte models in vitro: the need for mineralised extracellular matrix and network architecture

Osteocytes inhabit one of the most extreme cellular microenvironments in the human body: a hydrated, hierarchically structured mineralised extracellular matrix where lacunar confinement, canalicular connectivity, fluid transport and mechanics are inseparable from cell function. In vitro osteocyte models have rapidly ad...