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P. Chan

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Open access Sep 2026

Development of a Framework for Evaluating Large Language Model Safety and Reliability: a Proof-of-Concept Evaluation

Large language models (LLMs) are entering clinical decision support faster than methodology can characterise their safety. Aggregate accuracy treats all errors as interchangeable and cannot support safe deployment under Software as a Medical Device (SaMD) and EU AI Act frameworks. To develop and demonstrate a framework...

Fang-Yan Liu, Zhi Liu, Xiaolu Fei et al. · 0 citations
Open access Sep 2026

Unveiling the Distinctive Brain Functional Dynamics Between Parkinson's Disease and Progressive Supranuclear Palsy

ABSTRACT Background Dynamic analysis of resting‐state fMRI (rs‐fMRI) offers a novel approach to differentiate Parkinson's disease (PD) from progressive supranuclear palsy (PSP) by capturing temporal features of brain network activity, which may shed light on the mechanisms underlying non‐motor symptoms. Objectives To c...

Chen-Fei Ye, Jia-Hui Shi, Ji-Liang Fang et al. · 0 citations
Open access Jul 2026

Striatal Tau Pathology Underlies Monoaminergic Disruption in Progressive Supranuclear Palsy

The pallido-nigro-luysian axis and nigrostriatal system serve as sensitive targets for detecting tau deposition and monoaminergic disruption in PSP and local striatal tau pathology and tau burden were associated with monoaminergic disruption in PSP.

Chong Dong, Jing-Hong Ma, Hong-Gang Qiao et al. · 0 citations

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