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Sep 2026

Exploring the Potential of Quinoline-Containing Pyrazoline Derivatives as Antidepressant Agents: In Vivo and In Silico Studies.

INTRODUCTION/OBJECTIVE Depression is a common mental disorder, affecting over 300 million people worldwide. Currently available treatments, such as SSRIs, SNRIs, TCAs, and MAOIs, have limited effectiveness and cause side effects. The pharmacological potential of compounds based on diverse novel heterocyclic scaffolds,...

B. Sharma, Chahat, Pawan Kumar et al. · 0 citations
Open access Sep 2026

Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐Yl) Derivatives as EGFR Inhibitors Targeting EGFRWT , EGFRT790M , and EGFRL858R /T790M/C797S in NSCLC

A series of novel N‐Cinnamamide/benzamide‐(4‐(substituted phenyl)‐6‐(4‐cyclohexylphenyl)pyrimidin‐2‐yl) derivatives (Ri–Rxii) as EGFR inhibitors exhibited superior antiproliferative activity against wild‐type and mutant EGFR‐driven NSCLC cell lines, and was a strong candidate for overcoming drug resistance in NSCLC tre...

Rohit Pal, G. S. P. Matada, Ghanshyam Teli et al. · 0 citations

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