Mitochondria integrate bioenergetics, redox signalling, calcium handling, biosynthesis, apoptosis, and stress responses. Their contribution to ageing depends less on any single pathway than on the ability to sustain these functions through continuous maintenance, remodelling, and inter-organelle communication. This rev...
P. Chmielewski· Biogerontology (Dordrecht)· 0 citations
Biological aging is accompanied by persistent tissue-damage signaling, chronic inflammation, extracellular matrix remodeling, cellular senescence, and declining regenerative capacity. Taken together, these features resemble an injury response that is repeatedly initiated but fails to progress reliably through clearance...
P. Chmielewski, Bartłomiej Strzelec· International Journal of Mol...· 0 citations
This work evaluates the mechanistic and translational evidence for all twelve hallmarks of aging framework and examines RNA-processing defects and extracellular matrix remodeling as candidate processes without classifying either as an additional hallmark.
P. Chmielewski, Bartłomiej Strzelec· International Journal of Mol...· 0 citations
Alzheimer’s disease (AD) is the leading cause of dementia and a heterogeneous neurodegenerative disorder characterized by amyloid-β (Aβ) and tau pathology, impaired proteostasis, neurovascular dysfunction, maladaptive glial and immune responses, and synaptic dysfunction. Human genetic evidence supports an upstream role...
Improved molecular, spatial and functional resolution of senescent states will be essential for developing biomarker-guided and tissue-specific interventions that preserve the beneficial functions of transient senescence while limiting its chronic deleterious effects.
P. Chmielewski· Biogerontology (Dordrecht)· 1 citation
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