Amyotrophic lateral sclerosis (ALS) shows well-established sex differences in incidence, age at onset and progression, but their biological basis is unclear. We hypothesised that the DNA methylation changes associated with ALS differ between the sexes, which would point to sex-specific disease processes. To test this,...
Young Jun Kim, A. Iacoangeli, R. Zwamborn et al.· bioRxiv· 0 citations
A new model is developed that is validated across diverse ALS populations, can handle discrepancies between genotyping technologies, and is applicable to individual external samples, and has the potential to extend genetic risk assessment to all individuals, regardless of their family history or the presence of known A...
Jia-Jing Hu, Oliver Pain, A. Al Khleifat et al.· Genome Medicine· 0 citations
Targeting upstream mechanisms of mitochondrial impairment may provide a unifying strategy for understanding ALS pathogenesis and developing effective therapies.
Hiroshi Mitsumoto, H. Blasco, P. Corcia et al.· Biomolecules· 0 citations
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