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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

P. Cossar

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Open access Aug 2026

14-3-3/Tau molecular glues modulate in vitro tau condensation

The intrinsically disordered protein Tau is highly phosphorylated under pathological conditions, which, among others, results in Tau liquid–liquid phase separation (LLPS), followed by aggregation. The hub protein 14-3-3 regulates Tau protein solubility and prevents LLPS by binding with phosphorylated Tau residues pS214...

Maxime C. M. van den Oetelaar, Leandre M. Ravatt, Francisco Maqueda Zelaya et al. · 0 citations
Open access Jul 2026

Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC

A molecular glue-stabilizer and PROTAC strategies are combined to enable ubiquitination of the 14-3-3/estrogen receptor α complex, revealing cooperative linker-dependent activity and a structural basis for targeted E3 ligase recruitment.

Carlo J. A. Verhoef, Charlotte Crowe, M. Nakasone et al. · 0 citations

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