Open access
Aug 2026
Subcellular pharmacology of a novel cell-permeable fluorescent phosphodiesterase inhibitor using advanced fluorescence microscopy
A cell-permeable fluorogenic analogue of the phosphodiesterase 4 (PDE4) inhibitor rolipram (MAN193), generated by conjugation to fluorescein diacetate is developed, establishing fluorogenic drug conjugation combined with quantitative spectroscopy imaging as a generalisable strategy to map intracellular drug–target enga...
Soumyabrata Banik, Michele Anselmi, Jagannath Sathpathy et al.
· bioRxiv · 0 citations