P. D. De Jager

High-Dimensional Multi-Omic Mapping of Post-Mortem Human Brain Using Iterative Indirect Immunofluorescence Imaging on Xenium-Processed Tissues

A post-spatial profiling workflow that combines the Xenium platform with iterative indirect immunofluorescence imaging (4i) on formalin-fixed paraffin-embedded (FFPE) human brain tissue to capture key pathological features for Alzheimer’s disease (AD) and facilitate cell segmentation is reported.

Evaluation of potential serum biomarkers for individuals at risk of multiple sclerosis highlights SPP1.

Circulating proteins have been widely investigated as potential biomarkers in multiple sclerosis (MS), yet findings across studies are often inconsistent, likely reflecting differences in disease stage, treatment exposure, and cohort composition. Studying individuals at elevated risk of MS prior to disease onset offers...

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility

Altered microglial communication in brains with Alzheimer’s Disease pathology

It was found that AD was characterized by altered microglial composition and rewiring of intercellular communication, including disease-specific signaling pathways and distinct interaction hubs.