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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

P. Desai

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Open access Jul 2026

TRPML1 loss drives lysosomal calcium failure and astrocyte dysfunction across Alzheimer’s Disease progression

It is found that astrocytic cytosolic calcium activity is suppressed prior to amyloid plaque deposition and is accompanied by reduced lysosomal acidification in vivo, identifying lysosomal failure as an initiating event in astrocyte dysfunction in AD.

D. Shah, P. Desai, C. Chertavian et al. · 0 citations
Open access Jul 2026

A proteomic signature for prognostic stratification in amyotrophic lateral sclerosis

This work indicates the utility of multiple proteins reflecting diverse biological pathways in refining survival stratification and highlights systemic factors in ALS progression, highlighting their potential role in measuring disease progression.

D. Lester, P. Piazza, E. Dellar et al. · 0 citations

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