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P. Dolce

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Open access Sep 2026

Bayesian Shrinkage Versus Frequentist Variable Selection in Small-Sample Translational Research: A Monte Carlo Simulation Study Grounded in Regenerative Medicine Biomarker Discovery

Introduction. Observational studies in regenerative medicine represent a promising frontier for the discovery of predictive biomarkers of therapeutic response, yet are structurally constrained by small sample sizes. This low-sample-size regime exposes variable selection methods to a high risk of overfitting and false d...

Michele Francesco Di Tolla, Domenico Iervolino, Vittorio Scisciola et al. · 0 citations
Review Open access Aug 2026

Heart Failure and Cancer: Incidence and Mortality Patterns, A Systematic Review and Meta-analysis.

The observed HF-cancer association is influenced by statistical methodology, shared risk factors, differences in surveillance intensity and cancer type, that confound analyses investigating possible causal biological links.

L. Sanasi, A. Iaconelli, Danila Azzolina et al. · 0 citations

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