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Open access Oct 2026

Early life stress induces transgenerational, age-dependent cardiac dysfunction through epigenetic activation of BMP10

Early life stress (ELS) in childhood due to physical or sexual violence, parental neglect, or trauma has been recently associated with an increased risk of cardiovascular disease in later life. However, the mechanisms linking ELS to cardiovascular impairment remain unexplored. To investigate whether ELS in...

P. Enz, S. Mohammed, M. Telesca et al. · 0 citations
Open access Oct 2026

Immune–metabolic crosstalk between T cells and interstitial macrophages drives pulmonary vascular remodeling in cardiometabolic HFpEF

Pulmonary hypertension (PH) is a common and prognostically adverse complication in obese patients with heart failure with preserved ejection fraction (HFpEF). Cardiometabolic HFpEF-associated PH (PH-cHFpEF) is characterized by inflammation and metabolic dysregulation. Alterations in pulmonary immune cell populati...

V. Masciovecchio, M. Telesca, I. Papadopoulou et al. · 0 citations

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