P. F. V. Do Prado

Structure of the human mitochondrial RNA degradosome reveals a distinct mode of helicase–nuclease coupling

RNA degradation shapes cellular and organellar gene expression. In human mitochondria, this process is mediated by a dedicated degradosome comprising the helicase SUV3 and the exoribonuclease PNPase, but how these enzymes assemble and cooperate to degrade structured RNA has remained unknown. Here, we report the cryo-EM...