Author

P. Fariselli

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Open access Sep 2026

Metabolic dysregulation linked to sickling tendency in sickle cell anemia independent of HbF.

Sickle cell disease (SCD) presents substantial interindividual clinical variability that remains only partially explained by genotype, fetal hemoglobin (HbF), and co-inherited alpha-thalassemia. We investigated whether endogenous metabolites modulate the sickling tendency, independently of HbF. We analyzed 368 steady-s...

S. van der Veen, A. Idrizovic, T. Sanavia et al. · Blood Cells, Molecules & Dis... · 0 citations

#artificial intelligence Preprint Sep 2026

Human mutation field reveals an equilibrium-like structure with irreversible circulation

A thermodynamic decomposition of the human mutation field is given: most mutation bias is organized by a local equilibrium-like energy landscape aligned with genome composition, while the residual circulation points to specific directional mutational mechanisms.

Isabella Caranzano, D. M. Busiello, Stefano Priorelli et al. · 0 citations

Open access Aug 2026

A generative model for dimensionality reduction with millions of features and few samples

It is demonstrated that it is feasible to train a deep generative model for dimensionality reduction with millions of features using few samples, which makes this type of generative model a more versatile alternative to standard methods for dimensionality reduction.

C. Pancotti, P. Fariselli, J. Meisner et al. · bioRxiv · 0 citations