Structural insights into human caspase-9 CARD assembly modes driven by conserved arginine hotspots
Caspase-9 (C9) is a key initiator of the intrinsic apoptotic pathway and contains an N-terminal caspase activation and recruitment domain (CARD) that mediates homotypic and heterotypic interactions. While previous studies have shown that C9CARD can form filamentous assemblies under specific conditions, its intrinsic st...