Open access
Oct 2026
Towards VDAC pharmacology: Developing small-peptide channel inhibitors inspired by nature
The Voltage-Dependent Anion Channel (VDAC) forms a unique pathway across the mitochondrial outer membrane for small ions and water-soluble metabolites, such as ATP and ADP. Despite VDAC’s involvement in both normal regulation of respiration and in a wide variety of mitochondria-associated pathologies, there are, surpri...
T. Rostovtseva, P. Gurnev, D. Hoogerheide et al.
· bioRxiv · 0 citations