Author

P. Harshitha

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Review Open access Aug 2026

Characterizing the molecular mechanisms underlying aluminium-induced disruptions in neuronal survival pathways

Substantial changes in key signalling pathways, such as the IL-1β/JNK, PI3K/Akt/mTOR, Nrf2/Ho-1, System Xc-/GPX4, and NLRP3 inflammasome activation pathways, were observed and highlight aluminium as a potent modulator of neuronal survival pathways, driving neurodegeneration through multifactorial mechanisms.

K. Sravya, Arpitha Rao, P. Harshitha et al. · Metabolic brain disease · 0 citations

Review Open access Sep 2026

Molecular Basis of Ferroptosis and Pyroptosis in Lead-Induced Neurotoxicity: A Narrative Review of Current Evidence and Therapeutic Implications.

Lead (Pb) is a well-established potent neurotoxicant. Biochemically, overexposure to Pb is associated with alterations in synaptic signaling and neurotransmission, causing disruptions in neuronal activity and hence resulting in the manifestation of developmental-related disorders. Furthermore, lead-induced neurotoxicit...

S. Suvashini, P. Harshitha, Aluru Parithathvi et al. · Biological Trace Element Res... · 0 citations