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P. He

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Open access Aug 2026

A cfDNA fragmentomics-based liquid biopsy assay for early detection of oral cancer

Early detection of oral cancer improves outcomes, but remains limited by the invasiveness and low sensitivity of current screening methods. This study included 342 participants (200 in the training and 142 in the validation cohorts). Plasma cfDNA underwent low-depth whole-genome sequencing, with data norma...

Weiwei Wang, Tao Ding, Cuicui Liu et al. · 0 citations
Open access Aug 2026

Generalizable cancer detection from ultra-low-pass WGS via deep contextual modeling of cfDNA sequences

Fragmentia-AI™ WGS, a mutation-calling-independent framework that uses a transformer-based multiple-instance learning architecture with sequential fine-tuning across tumor fraction (TF) strata to extract latent cancer-associated signals from ULP-WGS data, enables robust cancer detection and clinically meaningful risk s...

Yang Xu, Song Wang, Guo-Feng Sun et al. · 0 citations

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