Author

P. Holmans

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Open access Jul 2026

Polygenic associations with phenotypic classes across the psychosis-affective spectrum

Introduction Limitations of current classifications of schizophrenia, schizoaffective disorder, and bipolar disorder are evident from their overlapping symptoms, aetiologies, treatments, and outcomes, and present a barrier to novel treatment discovery. Alternative conceptualisations are needed to address nosological va...

Charlotte A. Dennison, S. Legge, A. Cardno et al. · medRxiv · 0 citations

Open access Jul 2026

Identifying and Characterising Common Genetic Differences in Schizophrenia and Bipolar Disorder

Case-Case GWAS is used to identify common genetic variants differentially associated with schizophrenia and bipolar disorder, analysing 67,390 schizophrenia cases and 41,917 bipolar disorder cases and demonstrating that genuine divergent genetic effects exist beyond the substantial shared liability.

I. Willcocks, A. Richards, S. Legge et al. · medRxiv · 0 citations