P. Huesgen

A single-amino-acid cleavage controls global mitochondrial complex integrity.

Mitochondrial proteostasis depends on precise N-terminal processing of imported precursor proteins. Defects in this maturation step are implicated in disease, yet the functional impact in humans remains unclear. Here we show that the intermediate cleaving peptidase ICP55, which removes a single amino acid, acts as a ke...

Powering methanogenesis from fatty acids by a twin-heme-mediated reverse redox-loop

Regulation of Sulfolobus acidocaldarius surface structures by the PP2A core interaction module

Protein phosphorylation is a central regulatory mechanism that enables organisms to adapt to changing environmental conditions. The hyperthermophilic archaeon Sulfolobus acidocaldarius encodes only two phosphatases: the dual-specificity phosphatase PTP and the serine/threonine phosphatase PP2A. PP2A has previously been...

Fractionated proteomics identifies a protein network mitigating resistance exercise-induced damage in human skeletal muscle

This study reveals molecular responses of untrained, adapted and deadapted human skeletal muscle to resistance exercise, which identifies a network of mechanosensory proteins and molecular chaperones that ensures skeletal muscle homeostasis in humans.