P. Hunter

High reelin expression may explain why a subgroup of entorhinal cortex neurons functions as an initial nucleation site of Alzheimer’s disease

It is shown that, in a senescent physiology predisposing to frequent inflammation-driven Aβ42 production bursts over a decades-long period, the intracellular amount of Aβ42-reelin complexes can accumulate to extraordinarily high levels in anterolaterally positioned LII neurons compared to the vast majority of cortical...