Author

P. J. Lucassen

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Open access Oct 2026

The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time

BACKGROUND Cognitive resilience to Alzheimer’s disease (AD) can be modelled in amyloid-expressing rodents through early handling (EH). This study investigated how EH and sex affect cognition and pathology over time. METHODS We assessed cognition (open field, object recognition test, Barnes maze) in 6- and 12-month-old...

M. Carrigan, Jeniffer Sanguino-Gómez, Melis Bayer-Var et al. · bioRxiv · 0 citations

Open access Sep 2026

Voluntary physical activity modulates brain ΔFOSB and alters co-activation networks in male and female mice.

Regular physical activity promotes brain health, yet the underlying mechanisms remain incompletely understood. Repetitive activation of neurons results in accumulation of the nuclear transcription factor ΔFOSB, a long-lived splice variant of FOSB. Long-term voluntary wheel running (VWR), a behavioral paradigm that mimi...

Marene H. Hardonk, Rick Wenning, J. Stofberg et al. · eNeuro · 0 citations