INTRODUCTION
The global rise of invasive and drug-resistant Candida infections has intensified the need for antifungal agents with novel mechanisms of action. Conventional classes of systemic drugs face limitations due to toxicity, pharmacokinetic constraints, and increasing fungi resistance, particularly among C. glab...
M. Kłos, Monika Janeczko, B. Mickiewicz et al.· Future Medicinal Chemistry· 0 citations
ABSTRACT Aims Despite growing interest in metallacarborane biological activity, the molecular targets underlying their antifungal activity remain unknown. This study aimed to identify protein targets of antifungal metallacarborane derivatives in Candida albicans and to characterize their interaction with the molecular...
K. Kubiński, Paweł Czubak, Aleksandra Martyna et al.· Future Medicinal Chemistry· 0 citations
This Perspective surveys the dominant trends shaping contemporary organic synthesis in the context of drug discovery-late-stage C─H functionalization, photoredox and electrochemical catalysis, biocatalysis, continuous flow manufacturing, AI-guided retrosynthesis, DNA-encoded libraries (DELs), and proximity-based modali...
P. Kozyra, M. Masłyk· Chemistry· 0 citations
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