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In older adults, circulating biomarkers and PGSs provide cumulative information for CVD risk prediction, contributing differently to discrimination and risk reclassification.
This investigation investigated whether selective integration of lipidomic and genomic risk signals into AusCVDRisk improves 5-year CVD prediction and reclassification, with a focus on individuals at intermediate clinical risk.
The hypothesis‐generating findings suggest triglyceride‐related genetic variation may identify individuals with differential responses to aspirin, and suggest triglyceride‐related genetic variation may identify individuals with differential responses to aspirin.
Higher diet quality is associated with a lower risk of depressive symptoms, independent of genetic predisposition or low-grade inflammation, which may support dietary interventions as a modifiable lifestyle strategy for mental health promotion and prevention in older adults.
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