Author

P. Laise

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Sep 2026

Abstract IA02: Single-cell regulatory network analysis of therapy-associated cell state remodeling to inform combination strategies in osteosarcoma

A single-cell regulatory network analysis of therapy-associated cell state remodeling to inform combination strategies in osteosarcoma and single-cell profiling reveals drug effects missed by bulk efficacy measures is extended.

J. Pavisic, Chelsey M. Burke, Dao-Qi You et al. · Cancer Research · 0 citations

Open access Aug 2026

Developmental and MAPK-responsive transcription factors regulate distinct malignant cell states and associated genetic dependencies in pancreatic cancer

The authors apply ARACNe and metaVIPER to published scRNA-seq datasets to characterize pancreatic cancer subtypes, identifying six distinct cell states as well as their mechanistic determinants.

P. Laise, Mikko M. Turunen, Álvaro Curiel-García et al. · Nature Genetics · 1 citation