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P. Lehmann

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Open access Jul 2026

Evaluating memory B cell cross-reactivity between ancestral and future SARS-CoV-2 variants — evidence for original antigenic sin 2219641

To investigate whether human donors with verified SARS-CoV-2 infection in early 2022, likely with Omicron (BA.1), generated variant-specific Bmem responses or whether WH1-reactive Bmem were preferentially boosted, a novel ImmunoSpot assay was established to assess cross-reactivity at single-cell resolution.

G. Kirchenbaum, Lingling Yao, N. Becza et al. · 0 citations

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