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Open access Oct 2026

Longitudinal high-sensitivity C-reactive protein assessment predicts cardiovascular risk in apparently healthy individuals

High-sensitivity C-reactive protein (hsCRP) is the guideline-recommended biomarker for assessment of residual inflammatory risk in atherosclerotic cardiovascular disease (ASCVD). Clinical adoption remains limited, especially in individuals without established ASCVD. This study used longitudinal measurements to ev...

B. Kurt, M. Reugels, K. Schneider et al. · 0 citations
Open access Oct 2026

Prognostic impact of high-sensitivity C-reactive protein trajectories and sustained residual inflammation for prediction of cardiovascular outcomes

Traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) fail to fully reflect the residual risk, driven by chronic low-grade inflammation, observed in many. Generally, high-sensitivity C-reactive protein (hsCRP) concentrations remain stable, but some individuals may experience increases. More...

F. Kahles, M. Reugels, K. Schneider et al. · 0 citations
Open access Oct 2026

Associations between mosaic chromosomal alterations and incident cardiovascular disease in 419,000 individuals

Clonal hematopoiesis refers to the age-related clonal expansion of blood stem cells with genomic alterations and is linked to cancer and other adverse outcomes. These genomic alterations range from single-nucleotide variants or short insertions/deletions, termed clonal hematopoiesis of indeterminate potential (CH...

S. Flynn, A. Schuermans, S. Zelavat et al. · 0 citations

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