Author

P. Meinke

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Open access Aug 2026

MBNL depletion drives stem cell fusion and immature myonuclear states in myotonic dystrophy type 1

It is shown that muscle stem cells are activated and fuse with existing muscle fibres in myotonic dystrophy type 1, producing centrally located nuclei with altered gene-expression states and reshaping diseased muscle.

Vanessa Todorow, X. Lornage, Shinichiro Hayashi et al. · Nature Communications · 0 citations

Open access Jul 2026

Elimination of myotonia improves myopathy in a muscleblind-like knockout model of myotonic dystrophy

A cardinal sign of myotonic dystrophy type 1 (DM1) is myotonia, slow muscle relaxation after voluntary contraction. Myotonia results from mis-regulated splicing of chloride channel 1 (ClC-1), leading to loss of channel function and runs of involuntary action potentials in muscle fibers. Preceding the onset of weakness,...

Matthew T. Sipple, S. Hamazaki, Vanessa Todorow et al. · Nature Communications · 0 citations