P. Muñoz-Cánoves

An integrative transcriptomic atlas of ALS and aging skeletal muscle defines shared and distinct molecular programs of degeneration.

Skeletal muscle atrophy and weakness resulting from loss of motor neuron innervation are shared hallmarks of amyotrophic lateral sclerosis (ALS) and age-associated sarcopenia. However, muscle wasting in ALS is rapid and severe, whereas sarcopenia progresses gradually over decades, peaking at an advanced age. The molecu...

The hallmarks of skeletal muscle health

Skeletal Muscle Stem Cells: Aging and Rejuvenation.

This work focuses on the age-associated intrinsic changes of SCs and the causes of their cellular and molecular decline, and discusses results from single-cell omics technologies that have shed light on the interactions between SCs and niche cells and how far-reaching signals impact SC function.

Multimodal brain cell atlas across the adult macaque lifespan.

A comprehensive transcriptomic and chromatin accessibility atlas of 8 brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals establishes a foundational framework for understanding the cellular and regulatory architecture of primate brain aging and its links t...