P. Musienko

Monoamine receptors of intrinsic spinal neurons and their role in mammalian locomotor control: from physiology to pathology

Abstract Locomotor impairment is one of the most devastating consequences of spinal cord injury (SCI) and cannot be adequately overcome by existing rehabilitation methods. Numerous studies in spinalized mammals have demonstrated that serotonin, dopamine, and noradrenaline receptors located on spinal cord cells below th...

Peptide-based allosteric modulators of AMPA receptors: design, docking and ligand-receptor interactions.

Mechanisms of Serotonergic Modulation of Glial Cell Functions in the Recovery Period After Spinal Cord Injury

The serotonergic system represents a promising but complex target for inducing neuroplasticity processes; success requires the development of subtype-selective ligands and treatment protocols that take into account the stages of pathological processes in SCI.

Neurobehavioral Effects of Two Distinct Anti-Inflammatory Drugs in a Two-Week Chronic Stress Model in Zebrafish

Overall, the findings suggest that the two anti-inflammatory drugs tested modulate behavioral and molecular responses to chronic stress in zebrafish, with minocycline demonstrating broader anti-neuroinflammatory and antidepressant-like effects, and nimesulide exhibiting more specific anxiolytic-like properties in this...