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Author

P. Muthenna

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2 papers indexed here

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2026

Designing Ten New Drug Candidates to Block HIV-1 Integrase: A Computational Study Targeting the Enzyme's Magnesium-Dependent Active Site

Human Immunodeficiency Virus type 1 (HIV-1) integrase is an essential enzyme that inserts viral DNA into human host cell genomes. Rising clinical resistance to established integrase strand transfer inhibitors (INSTIs) necessitates novel therapeutic strategies. Here, we designed ten de novo small-molecule inhibitors (NI...

P. Muthenna · 0 citations
Open access 2026

De Novo Design of Novel Pks13 Inhibitors Rational Drug Design via Machine Learning-Guided Molecular Docking and QSAR Modelling for Mycobacterial Mycolic Acid Biosynthesis Inhibition

Tuberculosis remains one of the world's most significant infectious diseases, with approximately 10 million new cases annually. The polyketide synthase 13 (Pks13) enzyme, responsible for the final cyclopropanation step of mycolic acid biosynthesis, has remained understudied as an antituberculous drug target despite its...

P. Muthenna, Anugula Chandra Shekhar · 0 citations

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